A 32-year-old patient with end-stage renal failure has irreversible neuromuscular blockade two hours after tracheal intubation with a muscle relaxant. Which of the following is the most likely cause?
During frontal craniotomy for removal of an astrocytoma, the surgeon notes that the brain is "tight." The patient is receiving nitrous oxide 50% in oxygen, isoflurane 0.5%, fentanyl, and pancuronium. Heart rate is 92 bpm, blood pressure is 110/60 mmHg, end-tidal carbon dioxide tension is 31 mmHg, and oxygen saturation is 98%. The most appropriate initial treatment is to
(A) administer a beta-adrenergic blocker
(B) administer thiopental
(C) decrease isoflurane concentration
(D) decrease mean arterial pressure to 60 mmHg
(E) increase alveolar ventilation
E
The potency of an inhalational anesthetic correlates best with its
(A) vapor pressure
(B) blood/gas partition coefficient
(C) molar volume
(D) brain/gas partition coefficient
(E) oil/gas partition coefficient
E
During apneic oxygenation (FiO2 1.0) through a rigid bronchoscope
(A) duration of the procedure is limited by the increase in PaCO2
(B) functional residual capacity decreases 5%/min
(C) PaO2 remains unchanged for the first 5 minutes
(D) PaCO2 increases 2 to 6 mmHg/min for 15 minutes and then reaches a plateau
(E) PaO2 and PaCO2 equilibrate with mixed venous gases at the same rate
Which of the following antihypertensive drugs is most likely to cause bradycardia?
(A) Captopril
(B) Clonidine
(C) Hydralazine
(D) Nifedipine
(E) Phenoxybenzamine
B
A healthy, 18-year-old, 65-kg woman undergoing diagnostic laparoscopy is being monitored with a properly functioning and calibrated capnograph. The end-tidal carbon dioxide concentration is 6%, and the inspired carbon dioxide concentration is 1%. This may be caused by each of the following EXCEPT
(A) malfunction of the expiratory valve in a circle system
(B) low gas inflow with a Bain circuit
(C) exhausted soda lime within a circle system
(D) absorption of carbon dioxide from carbon dioxide laparoscopy