During isoflurane anesthesia, a 45-year-old patient with chronic asthma has wheezing, prolonged expiration, sinus tachycardia of 120 bpm, and premature ventricular contractions. Preoperative medication included cromolyn and theophylline. The most appropriate treatment is to administer
Thirty-six hours after primary repair of meningomyelocele, a term newborn has frequent periods of apnea lasting 25 seconds and associated with oxygen desaturation to 80%. The most likely explanation is
A 75-year-old, 60-kg man with moderately disabling heart failure secondary to ischemic heart disease is undergoing a transurethral prostatic resection under halothane-nitrous oxide anesthesia. Resection time is 30 minutes, and fluid replacement has been lactated Ringer's solution 500 mL. Although heart rate is unchanged, the arterial pressure monitor used because of his cardiac condition has changed from A to B over the last 15 minutes. The most appropriate management is to
(A) discontinue halothane
(B) adminster ephedrine 10 mg intravenously
(C) administer digoxin one half of his daily dose intravenously
Which of the following is characteristic of the pharmacokinetics of alfentanil?
(A) Clearance is greater than that of fentanyl
(B) Elimination half-life is normal in patients with hepatic insufficiency
(C) Protein binding is minimal
(D) The majority of alfentanil in plasma is ionized
(E) Volume of distribution is smaller than that of fentanyl
E
A 35-kg child requires mechanical ventilation with pure oxygen at a tidal volume of 350 ml and a rate of 20/min during a severe asthma attack. The most likely cause of severe hypotension after initiating mechanical ventilation is