A 70-kg, 46-year-old man is undergoing clipping of a cerebral aneurysm with nitrous oxide, opioid, relaxant anesthesia. He is otherwise healthy. As the surgeons are about to enter the dura, the brain is noted to be tense and bulging. Heart rate is 100 bpm and mean arterial pressure is 90 mmHg. PaO2 is 120 mmHg, PaCO2 is 23 mmHg, and pH is 7.50. Which of the following should be done immediately?
(A) Hyperventilation to a PaCO2 of 15 to 20 mmHg
(B) Administration of furosemide 20 mg intravenously
(C) Administration of mannitol 0.5 g/kg
(D) Administration of thiopental 250 mg in increments
During laser microsurgery of the larynx using an endotracheal tube, a fire occurs in the airway. Which of the following is the most appropriate initial management?
A blood sample is taken from a patient whose body temperature is 30°C. In which direction will the pH, PCCX, and P02 change when measured in the blood gas machine at 37°C? (pH, PCO2, PO2)
(A) Increase Decrease Decrease
(B) Decrease Increase Increase
(C) Decrease Increase No change
(D) No change Increase Increase
(E) No change No change Increase
B
Which of the following differentiates midazolam from diazepam administered intravenously in equipotent doses?
(A) Greater hemodynamic stability
(B) Lack of active metabolites
(C) Less respiratory depression
(D) Longer duration of action
(E) More rapid onset
B
Which of the following statements concerning pipecuronium is true?